Pre-Clinical – Safety, Tolerability, and Bioavailability

Our scientific research team at FRL has conducted extensive research in this area and offer an expert advice in all areas related to pre-clinical research. We offer wide range of services under pre-clinical services, and this includes

• Develop research protocol that adheres to the principles of the Declaration of Helsinki and in compliance with the international Council on Harmonisation Guidelines for Good Clinical Practice (GCP).
• We help you to register on the ClinicalTrials.gov database
• Dosage form performance assessment: Deciding the efficacious dosage range, while providing sufficient safety margins for evaluating the effects of formulation or food.
• Conducting bioavailability study with our partnered / networked hospitals
• Pharmacokinetic studies: Conducting pharmacokinetic and pharmacodynamic analyses through HPLC and mass spectrometry detection (HLPC/MS) and standard non-compartmental analysis method
• Statistical analysis and data management strictly adhering to ICH and GCP guidelines
• Safety evaluation by monitoring for adverse events (AEs), and by performing vital sign measurements (e.g., oral temperature, respiration rate, heart rate), clinical laboratory test, physical examination.

At FRL, we are dedicated to advancing the field of health research through cutting-edge Preclinical Studies ensuring that your research goals are met with precision and expertise.

Efficacy Studies (In Vitro & In Vivo): Our Preclinical Studies encompass both In Vitro (laboratory-based) and In Vivo (animal-based) efficacy assessments. Whether you are exploring the potential of a new compound or evaluating treatment options, we provide robust methodologies and state-of-the-art facilities to validate your research.

Antioxidant: Understanding the antioxidant properties of substances is crucial in health research. Our studies enable you to assess the ability of compounds to combat oxidative stress, supporting the development of antioxidant-rich formulations.

Diabetes Management: In the quest for effective diabetes management, FRL offers preclinical studies to evaluate the impact of interventions on glucose regulation, insulin sensitivity, and diabetic complications.

Eye Health: Protecting and enhancing eye health is a vital aspect of overall well-being. Our research services cover a wide range of studies related to eye health, including vision enhancement and ocular disease management.

Immunomodulatory & Inflammation: Discover the immunomodulatory and anti-inflammatory potential of your compounds through our specialized preclinical studies. Uncover innovative solutions for managing immune-related disorders and inflammation.

Hepatoprotective: Liver health is paramount. Our studies assess the hepatoprotective properties of substances, aiding in the development of treatments for liver diseases and conditions.

Obesity/Weight Management: Combat the global challenge of obesity with our preclinical studies. Evaluate the efficacy of interventions in weight management, metabolism, and obesity-related health issues.

Digestive & Probiotics: Optimize digestive health and explore the benefits of probiotics. Our studies delve into the effects of substances on gastrointestinal well-being and the gut microbiome.

Cardio/Heart Protective: Cardiovascular health is a priority. Our preclinical research evaluates interventions aimed at safeguarding the heart, improving circulation, and managing cardiovascular diseases.

Women's Health: Addressing women's unique health needs is a focal point of our research. Explore solutions for women's health issues through specialized preclinical studies.

Joint & Muscle Health: Enhance mobility and well-being with our studies on joint and muscle health. Evaluate interventions for arthritis, muscle disorders, and joint-related concerns.

Gut Health: The gut-brain connection is a burgeoning area of research. Our studies explore how substances impact gut health and its influence on overall health.

Osteoporosis: Preventing and managing osteoporosis is a crucial aspect of bone health. Our studies assist in evaluating interventions for bone density and strength.