Cognitive Health

We develop organic or conventional based on the client specifications. We source both plant and animal-based ingredients to formulate food and nutraceutical products. The products will specifically address deficits accompanied by an impaired function of the limbic system, especially in the areas of the cerebral cortex, hippocampus and amygdala that play a role in cognition.

We use safe, inexpensive and proven ingredients from natural sources that would benefit mental health. We use nutrient-dense foods (vegetables, fruits, grains and fish), Mediterranean diet, Olea europaea, and Nigella sativa, bacopa monnieri, coenzyme Q10, Pycnogenol, vitamin E and C, EGCG isolated from green tea, resveratrol, curcumin, and probiotics . Our experts formulate a product using folic acid, S-adenosyl-methionine (SAMe), omega-3 fatty acids, and L-tryptophan as adjunctive therapies. SAMe, omega 3, methyl folate and Vitamin D, zinc, folic acid, vitamin C, tryptophan, Vitamin B12, and folate.

The formulation depends on the requirements and classifies them. For instance, we extract chemical constituents (active ingredients) such as nutrients and herbals [(e.g., Polysaccharides can be extracted from different plants such as Silybum marianum L. (milk thistle)], phytochemicals, polyunsaturated fatty acids, or extract probiotics, and prebiotics or nutraceutical enzymes. We also carry out formulation in non-traditional forms by fortification or recombinant nutraceuticals.

Guires's scientists and formulation experts develop products that could potentially prevent learning and memory deficits using different flavonoids (e.g. Luteolin from Crisium Japonicum), myricetin or baicalein, spinosin extracted from Ziziphus Jujuba var. spinose, Quercetin, naringenin, hesperitin, liquiritigenin, phloretin and acacetin

Guires's scientists and formulation experts develop products to enhance sensorimotor (e.g. genistein), puerarin and swertisin for attention function, especially in children with autism spectrum disorders. Berries for sustained attention and psychomotor speed and black currant juice for greater alertness, and wild green oat, on executive function. We offer formulations using Ginkgo biloba extract EGb 761, Pinus radiata bark extract, and pycnogenol

We can formulate the products in the form of ready-to-drink, ready-to-serve, ready-to-eat, ready-to-cook, ready-to-drink, ready-to-mix powders, and formulations along with soft or hard gels, capsules, tablets, syrups, gummies, or sachets containing a concentrated source of minerals, vitamins, or botanical extracts.

Guires's scientists and formulation experts identify new delivery mechanisms (such as liposomes) and research-active compounds to develop a highly functional strength product that provides the intended results. Our formulation experts ensure that the end product would meet the required pH, dispersibility, efficacious dosage, mouthfeel, flavour, odor and taste. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

Any ingredient incorporated into the formulation needs to achieve its intended function in the human body at the same time, must adhere to safety guidelines. At Guires, we substantiate this from many different types of investigation, including secondary research for existing ingredients or, if it's novel, publishing the work in reputable, peer-reviewed journals. Data for this will be derived from chemical comparisons and analysis, activities (e.g., ORAC or oxygen radical absorbance activities), testing in animal models, genomic/gene expression studies, in vitro bioassays and, most compelling of all, human clinical testing. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

We follow quality measures to ensure the products are safe from both the supplier and the buyer's perspectives. We carry out Marker Chemistry (e.g., HPLC, GC etc.), Microbiology tests (e.g., Pseudomonas, Salmonella, Escherichia Coli), heavy metal analysis (e.g., lead, arsenic, cadmium kept below the regulatory limits), Contamination (e.g., metal flakes from machinery), physical characteristics (e.g., powders for tablets must have low moisture content) and stability (e.g., the time for a product from initial production). We use compendium methods (USP and European Pharmacopeia) for an extensive validation process.

We follow a specific set of regulations that a product must adhere to. This includes manufacturing flow chart, solvents, quantitative ingredient lists, physical characteristics, GMO status, certifications, radiations, pesticide/chemical/ residue, contaminants, microbiology, allergens, animal derivation, and safety (Standard Material Safety Data Sheet – toxicity or clinical testing). We assist ensure to clear the ingredient supplier completes clearance through the target country’s regulatory agency prior to its inclusion in formulas. Through our years of experience, our team can speed up the acceptance and inclusion of new material. Our product development team complies with the Food, Drug and Cosmetics Act (FDA 2009), DSHEA and the Fair Packaging and Labeling Act (Federal Trade Commission 2011), safety and quality food and food supplements guidelines delineated by WHO and the United Nations Food and Agricultural Organization (FAO). Our team ensures to use only acceptable ingredients that are found in the International Nomenclature. We also adhere to the local country’s guidelines as per the client’s request, such as for the Japanese Ministry of Health, Labor and Welfare (MHLW), The Chinese Health Care Association (CHCA), China’s State Food and Drug Administration (SFDA) and FSSAI.