Digestive Health

Evidence shows that various functional foods (whole and extracts) and their low-molecular-weight phytochemicals help protect intestinal homeostasis of both small and large intestines in different stages of intestinal ailments. This happens through promoting intestinal epithelial renewal and barrier function, restoring intestinal flora, inhibiting intestinal inflammation and tumour growth and exerting intestinal cancer-preventive effects.

We develop organic or conventional based on the client specifications. We source both plant and animal-based ingredients to formulate digestive health. We use safe, inexpensive and proven ingredients from natural sources that would benefit epithelial renewal, barrier function, restoring intestinal flora, inhibiting intestinal inflammation, inhibiting tumour growth and exerting an intestinal cancer-preventive effect.

Our formulation scientists develop food, beverages and nutraceuticals that enhance gut health. This includes chrysin, galanging, kaempferol, and caffeic acid phenethyl ester, mint, industrial orange by-products, peanut shell, sword bean, lyceum ruthenicum Murray, Ginger /Curcumin, Mushrooms, Ginsenoside Rg1, Vitamin A, Cinnamon, Resveratrol, Non-psychotropic phytocannabinoids, pleurotu eryngii, broccoli, red raspberries, blueberry, vitamin D3, green tea, Red Pepper, Peppermint oil and polydatin and many more.

The formulation depends on the requirements and classifies them. For instance, we extract chemical constituents (active ingredients) such as nutrients and herbals [(e.g., Polysaccharides can be extracted from different plants such as Silybum marianum L. (milk thistle)], phytochemicals, polyunsaturated fatty acids, or extract probiotics, and prebiotics or nutraceutical enzymes. We also carry out formulation in non-traditional forms by fortification or recombinant nutraceuticals.

Pre-probiotics and synbiotics formulation for digestive health

Our formulation scientists develop fermented milk products by incorporating living micro-organisms (e.g. Lactobacillus rhamnosus GG, Lactobacillus reuteri, bifidobacteria and certain strains of Lactobacillus casei, the Lactobacillus acidophilus-group, Escherichia coli strain Nissle 1917, certain enterococci, especially Enterococcus faecium SF68, and the probiotic yeast Saccharomyces boulardii), high health benefits as in Lactobacillus plantarum isolates (PCS20, PCS22, PCS25 and PCS26) from Slovenian cheese with high antimicrobial and immunomodulatory capabilities

Prebiotic formulation

Today, only bifidogenic, non-digestible oligosaccharides (particularly inulin, its hydrolysis product oligofructose, and (trans)galactooligosaccharides), fulfil all the criteria for prebiotic classification. Our expertise can develop infant formula more breast-milk-like by the addition of fructo- and (primarily) galactooligosaccharides. Fructo-oligosaccharides (FOS) with prebiotics resistant starch and β-glucan, carbohydrate components of whole grains.

Nutraceutical formulation

We develop nutraceutical products based on fortified dairy products (e.g., milk) and citrus fruits (e.g., orange juice). Several naturally derived food substances have been studied in cancer therapies. Vitamin E, selenium, vitamin D, green tea, soy, and lycopene are examples of nutraceuticals widely studied in human health. Polyunsaturated fatty acids (PUFAs) (which include the omega-3 and omega-6 fatty acids) and phytochemicals also play an important role as healthy dietary bioactive compounds

Ayurvedic formulation

We develop prototypes for gastrointestinal health and disease using Ayurvedic Medicine, as well as other traditional systems of medicine, including Ulmus rubra (common name: slippery elm) and Glycyrrhiza glabra (common name: licorice), as well as the widely known polyherbal medicinal formulation (common name: triphala) of Emblica officinalis, Terminalia bellerica, and Terminalia chebula. In fact, The Nutrition Care (NC) Gut Relief Formula contains a combination of herbs and nutrients, including curcumin, Aloe vera, slippery elm, guar gum, pectin, peppermint oil, and glutamine shown to benefit the GI system. We can help you to formulate such prototypes.

Whole grain-based formulation

Whole grains are rich in fermentable carbohydrates that reach the gut: dietary fiber, resistant starch, and oligosaccharides. Whole grains are an important source of dietary fiber and grain fibers such as wheat, oats, barley, and rye increase stool weight, speed intestinal transit, get fermented to short-chain fatty acids, and modify the gut microflora. Wheat bran is particularly effective in increasing stool weight. On the other hand, carbohydrates, that comprise soluble and insoluble fibre, resistant starch (RS) and oligosaccharides of the raffinose family, all of which contribute to the low glycemic index (GI) of legumes, have been revealed to play a key role as modulators of intestinal microbiota, bowel motility, glucose homeostasis and cholesterolemia. Our FRL scientists can formulate products based on whole grains.

Legume seeds formulation

Legume seeds are rich in compounds resistant to digestion, mainly proteins and carbohydrates, which might exert beneficial effects on gut health. Resistant proteins, including protease inhibitors of the Bowman–Birk family and 2S albumin storage proteins like lunasin, have attracted the attention of the scientific community as gut, metabolic, immunological and hormonal regulators but also as anti-inflammatory and anti-carcinogenic agents within the gastrointestinal tract (GIT). Our FRL scientists can formulate products based on whole grains.

We can formulate the products in the form of ready-to-drink, ready-to-serve, ready-to-eat, ready-to-cook, ready-to-drink, ready-to-mix formulations along with soft or hard gels, capsules, tablets, syrups, gummies, or sachets containing a concentrated source of minerals, vitamins, or botanical extracts.

Guires's scientists and formulation experts identify new delivery mechanisms (such as liposomes) and research-active compounds to develop a highly functional bone strength product that provides the intended results. Our formulation experts ensure that the end product would meet the required pH, dispersibility, efficacious dosage, mouthfeel, flavour, odor and taste. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

Any ingredient incorporated into the formulation needs to achieve its intended function in the human body at the same time, must adhere to safety guidelines. At Guires, we substantiate this from many different types of investigation, including secondary research for existing ingredients or, if it's novel, publishing the work in reputable, peer-reviewed journals. Data for this will be derived from chemical comparisons and analysis, activities (e.g., ORAC or oxygen radical absorbance activities), testing in animal models, genomic/gene expression studies, in vitro bioassays and, most compelling of all, human clinical testing. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

We follow quality measures to ensure the products are safe from both the supplier and the buyer's perspectives. We carry out Marker Chemistry (e.g., HPLC, GC etc.), Microbiology tests (e.g., Pseudomonas, Salmonella, Escherichia Coli), heavy metal analysis (e.g., lead, arsenic, cadmium kept below the regulatory limits), Contamination (e.g., metal flakes from machinery), physical characteristics (e.g., powders for tablets must have low moisture content) and stability (e.g., the time for a product from initial production). We use compendium methods (USP and European Pharmacopeia) for an extensive validation process.

We follow a specific set of regulations that a product must adhere to. This includes manufacturing flow chart, solvents, quantitative ingredient lists, physical characteristics, GMO status, certifications, radiations, pesticide/chemical/ residue, contaminants, microbiology, allergens, animal derivation, and safety (Standard Material Safety Data Sheet – toxicity or clinical testing). We assist ensure to clear the ingredient supplier completes clearance through the target country’s regulatory agency prior to its inclusion in formulas. Through our years of experience, our team can speed up the acceptance and inclusion of new material. Our product development team complies with the Food, Drug and Cosmetics Act (FDA 2009), DSHEA and the Fair Packaging and Labeling Act (Federal Trade Commission 2011), safety and quality food and food supplements guidelines delineated by WHO and the United Nations Food and Agricultural Organization (FAO). Our team ensures to use only acceptable ingredients that are found in the International Nomenclature. We also adhere to the local country’s guidelines as per the client’s request, such as for the Japanese Ministry of Health, Labor and Welfare (MHLW), The Chinese Health Care Association (CHCA), China’s State Food and Drug Administration (SFDA) and FSSAI.