Cholesterol

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Cholesterol

Cholesterol is a waxy molecule that may be present in your bloodstream. Cholesterol is required by your body to produce healthy cells, but excessive cholesterol levels might raise your risk of heart disease. You might have fatty deposits in your blood vessels if you have high cholesterol, and these deposits eventually accumulate to the point that blood flow through your arteries is restricted. Those deposits can sometimes rupture and form a clot, resulting in a heart attack or stroke. High cholesterol can be passed down the generations, but it’s more typically the result of poor lifestyle choices, making it avoidable and curable. High cholesterol can be reduced by a nutritious diet, frequent exercise, and, in some cases, medication.

Offering Therapeutical support and Research-based technical solutions for Cholesterol

Cholesterol is linked to proteins and transported through the bloodstream, and lipoprotein is a mixture of proteins and cholesterol. Depending on what the lipoprotein transports, there are several forms of cholesterol, and they are as follows:

  • LDL (low-density lipoprotein) is a kind of cholesterol found in the (LDL). LDL cholesterol, sometimes known as 'bad' cholesterol, is responsible for transporting cholesterol particles throughout the body. LDL cholesterol accumulates in the walls of your arteries, hardening and narrowing them.
  • High-density lipoprotein (HDL) is a kind of cholesterol found in the (HDL). The "good" cholesterol, HDL, collects extra cholesterol and transports it to your liver.
  • Triglycerides, the fat found in the blood, is usually measured as part of a lipid profile. A high triglyceride level might also put you at risk for heart disease.

The first defence against high cholesterol is to make lifestyle changes such as exercising and eating a balanced diet. However, your doctor may prescribe medicine if you've achieved these crucial lifestyle changes but still have high cholesterol. The prescription or combination of drugs you choose is determined by several criteria, including your unique risk factors, age, health, and potential drug adverse effects. Among the most popular options are:

Statins: Statins prevent your liver from producing cholesterol by blocking a chemical it requires. As a result, your liver removes cholesterol from your bloodstream. Atorvastatin, fluvastatin, lovastatin , pitavastatin, pravachol , rosuvastatin, and simvastatin are some of the options.

Inhibitors of cholesterol absorption:  The cholesterol in your meal is absorbed by your small intestine and released into your circulation. The medicine ezetimibe (Zetia) lowers blood cholesterol by preventing the absorption of dietary cholesterol. Ezetimibe can be taken in conjunction with a statin medication.

Bempedoic acid: This newer medicine works similarly to statins but has a lower risk of causing muscular soreness. Adding bempedoic acid (Nexletol) to a high-dose statin can considerably cut LDL. Nexlizet is a combination tablet that contains both bempedoic acid and ezetimibe.

Resins :

Your liver uses cholesterol to produce bile acids, which are essential for digestion. By binding to bile acids, the drugs cholestyramine (Prevalite), colesevelam (Welchol), and colestipol (Colestid) decrease cholesterol indirectly. This causes your liver to utilise extra cholesterol to produce more bile acids, lowering cholesterol levels in your blood.

Inhibitors  for PCSK9:

These medicines can aid in the absorption of LDL cholesterol by the liver, lowering the quantity of cholesterol in your blood. Persons with a hereditary disorder that produces very high levels of LDL or people with a history of cardiovascular disease who have sensitivity to statins or other cholesterol drugs may benefit from alirocumab (Praluent) or evolocumab (Repatha). Every several weeks, they are injected beneath the skin.

Guires’s research team continuously strives to identify new ways to control blood cholesterol. We are also involved in researching and developing highly functional foods that help maintain moderate cholesterol levels while protecting the cardiovascular system without any side effects

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