Screening and base optimization of anti-hangover gummies

client

Anti Hangover Gummies

Our Role

We redefined fast-casual loyalty

Today’s Task

What We did Today?

Event: Functional Gummy Prototyping

Today’s task focused on building a prototype for an anti-hangover gummy. We aimed to develop a chewable product with ingredients that support liver function, hydration, and replenishment. The biggest challenges we faced during development were optimizing functional dosage, texture, flavor/aroma, and taste without compromising the efficacy limit of ingredients.

How I Felt Before Starting – Curious to Combine Tradition with Functional Fermentation

I was excited but cautious. I faced initial challenges in screening active ingredients that provide both functional benefit and are within regulatory limits through a literature review. I was particularly careful in selecting botanical ingredients that don’t taste bitter and overpower the taste of other ingredients.

Anti Hangover
Anti Hangover
Anti Hangover
Anti Hangover

🧪 What We Did Today

Product Development Plan

We approached the formulation & optimization in three major phases:

  1. Identify safe, functional ingredients that support hydration, liver detox, and antioxidant action.
  2. Develop a neutral gummy base using a gelling agent and natural sugars.
  3. Run a compatibility trial and optimize taste, texture, and aroma by adjusting ingredient formulation.

Key Steps Followed Today:

We started our initial research by reviewing documents from medical resources and regulatory websites. Then, narrowed down potential active ingredient classes based on regulatory status and preliminary flavor profile. We selected all the ingredients that have science-backed human or clinical trials studies that have a strong effect on mitigating hangover discomfort.

We first started by preparing the base solution using water and a gelling agent. They were mixed thoroughly by stirring and mild heating.

The solution was cooled, followed by the addition of functional ingredients, sweeteners. oil, and active ingredients. It was then poured into a mould and frozen. Once gummies are ready, they are demoulded and packed in a sterile package for further analysis.

We conducted our quality testing and sensory analysis to check whether the final product meets all the requirements. We found that gummies produced at initial trials had a rough texture, light aroma, and bitter taste, at ambient RH > 60%.  We optimized this by cross-checking the ingredients list’s properties and identified that the phenolic content of a few active ingredients has overpowered sweeteners and flavouring agents.

So, in further trials, we planned to adjust the active ingredient ratio to suppress the bitter and off-taste, without compromising its efficiency. We then adjusted the gelling agent, water, and sugar quantities to soften the gummy.

📚 What I Learned?

  • Botanical actives may exhibit pro-oxidative degradation when handled at low moisture and high temperature.
  • Not all the botanical ingredients with a good oral bioavailability profile are suitable for a chewable delivery system.
  • The gummies required careful water activity balance to maintain chewable structure with herbal actives, without compromising preservation.

Outcome:

The final gummy product had a good texture with clean-label ingredients. However, initial trials showed the bioactives have overpowering taste and appearance, which are adjusted by further optimization trials. We further explored buffer systems and active protection techniques like encapsulation, coating, and taste modification for better integration.

✅ What Went Well?

  • Initial research established a strong theoretical and regulatory validated foundation for active class selection.
  • Base gummy achieved a clean mouthfeel and acceptable clarity.
  • Early red-flag identification in active botanical integration.

⚠️ What Could I Have Done Better

  • Could have prepared bitter masking options before full integration.
  • Should have conducted trials using encapsulation or butter versions of botanicals as well.
  • Could have explored additional delivery formats besides gummy for all shortlisted functional claims.
  • Could have designed a pre-formulation matrix to predict ingredient interaction and optimize ratio-dependent outcomes.

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